Synthesis golf started over summer, and a few nice targets have been used as problems.
When we started, the academic year (in the UK at least) hadn't begun, meaning a few of us had a quite a lot to time to spend around here - this has tailed off slightly now term has began so I thought it might be a nice idea to open up the floor to suggestions for targets for future rounds of synthesis golf.
Each month, we'll use one of the targets (that hopefully get posted) below.
Some ground rules to keep this sensible:
- The molecule must be predominantly organic. Small molecules with biological activity have been chosen for all previous rounds of synthesis golf, but there is no strict requirement that the target be biologically active.
- The molecule must be a published compound. It's fine if there are no published syntheses (for instance newly isolated natural products) but the actual target, along with unambiguous characterisation data must exist.
- The molecule should be complex enough to require some thought, but not so complicated that it would take a team of 5 PhD students a week to come up with a route. This has been one of the biggest challenges so far in finding targets but as a general rule of thumb, good targets would have 5 or fewer strereocentres that need controlling and somewhere under 15 carbon atoms.
Entries should include the following:
- The name of the target
- An image of the target
- A journal reference along with DOI for the target
- A brief summary of 1) why the molecule is interesting (i.e. biological activity) and 2) why you think it makes a good target