Capitalization of titles starting with chemical name with noncapitalizable prefix

Question

There is no question about if the first letter of the question title should be capitalized.

However, there are situations, when the capitalization of the very first first character is not possible, which however does not mean, that the capitalization should not occur at all. In many (most?) cases, the capitalization should occur at the first Latin letter, that is not part of a special prefix.

Usual cases are titles starting with a chemical name (or related term)

• starting with a digit
  Example: 2-Bromo-1-chloro-4-nitrobenzene reacts with sodium ethoxide
  External example: 1,3-Dipolar cycloaddition

• containing Greek or other non-Latin script prefix
  Example: α,β-Unsaturated carbonyl compounds and alkyl addition (TODO: FIX the title)
  External example: α,β-Unsaturated carbonyl compounds

• containing lowercase and italicised prefix
  Examples: p-Nitrophenol and sodium bicarbonate test (TODO: FIX the title),
  p-Phenylenediamine Production Process (TODO: FIX the title)
  It might not be possible to preserve entire typography in the title here at SE, however we still should preserve the case, I think.
  For cis-/trans- starting titles, we should differentiate if the initial prefix is part of the name, or a term, where the italicising does not usually occur (e.g. Trans-hydrogenation of alkenes seems OK).

Note that the proper capitalization style can be verified by the examples in the last IUPAC organic nomenclature, where the capitalization of chemical names was recommended, i.e. the 1979 version (see randomly chosen example(s) here).

Answer 1

I am an advocate for the title being an actual question, that would circumvent the capitalisation issue completely. I think the examples you brought up use oddly specific terms, while being very mysterious about the actual question. I would say the following titles would be much better options:

• What are the major products when 2-bromo-1-chloro-4-nitrobenzene reacts with sodium ethoxide?
• Is it possible to add alkyl groups in α,β-unsaturated carbonyl compounds using secondary amines?
• Why is carbon dioxide released when p-nitrophenol and sodium bicarbonate react?
• What is the production process for p-phenylenediamine?

While I think 'Trans-hydrogenation of alkenes' is somewhat okay, it would probably benefit from a better title, too.